In LUAD, multiple T-cell subsets (CD8+, CD45RO+, CD8+CD45RO+ and CD4+FoxP3+) showed closer proximity to tumour cells than in LUSC, which exhibited closer distances from tumour cells to T-cells expressing LAG-3, OX40 and TIM-3, and B-cells expressing OX40 and LAG-3. This evidence concerns the gene LAG3 and neoplasm.