This led to the introduction of the Immunoscore, which prognosticates patients with resected CRC more effectively than pathological tumour or nodal stage, microsatellite instability status, lymphovascular invasion and tumour differentiation despite measuring only two markers (CD3 and CD8) in two locations (tumour centre [TC] and invasive margin [IM]) [25,26]. This evidence concerns the gene CD8A and neoplasm.