Specifically, after multivariate analysis longer OS was found for close proximity to tumour cells of CD3+, CD3+CD8+GZMB+, CD3+CD8+CD45RO+, CD3+TIM-3+, CD3+ICOS+, CD66b+CD11b+ and CD20+ cells; longer OS was also seen for longer distance to tumour cells of CD3+CD8-FoxP3+, CD3+CD45RO+FoxP3+, CD3+CD8+PD-L1+, CD3+OX40+, LAG-3+ and CD68+PD-L1+ cells [78]. Here, ICOS is linked to neoplasm.