PGAM5 and hepatocellular carcinoma: PGAM5’s inhibitory role in apoptosis through BclXL dephosphorylation and enhancement of Drp1-mediated mitophagy have been correlated to its pro-cancer survival effect, wherein PGAM5 knockdown has been shown to attenuate hepatocellular tumor growth in vitro and in xenograft models of HCC [6,7,21].