While their immune functions are currently less well understood, researchers believe that CXCL-13-expressing T-helper cells play a significant role in attracting immune cells to the tumor microenvironment, regulating antigen-specific B-cell responses, and promoting the formation of tertiary lymphoid structures, thus generating germinal centers for local memory B-cell differentiation at the tumor location [48,49,50]. Here, CXCL13 is linked to neoplasm.