A detailed analysis of EBV+ patients between both patient populations showed an increase in the concentration of all molecules tested in CLL patients relative to CVID of 1.20-fold for sCD200; 1.50 times for sCD86; 1.73 times for sCD200R; 1.85-fold for sCTLA-4; 2.15 times for sPD-1; and 3.50 for sPD-L1 (Figure 8). This evidence concerns the gene SPDL1 and B-cell chronic lymphocytic leukemia.