These analyses confirmed that for both CLL and CVID patients, highly specific markers of EBV reactivation within the studied populations are: anti-EBV EA IgA and IgG; anti-EBV VCA IgA and IgM; and anti-EBV EBNA-1 IgA and IgG (Figure 9A,B). Here, CD40LG is linked to common variable immunodeficiency.