DNA hypermethylation of HOXA1 and TSPYL5 has been validated in three large clinical cohorts, and CLEC11A and AK055957 exhibited hypermethylation levels in HCC tissues compared to cirrhotic controls in a methylation intensity map [13], while limited information about the four DMMs in non-cirrhotic HCC can be found. This evidence concerns the gene TSPYL5 and hepatocellular carcinoma.