HOXA1 and hepatocellular carcinoma: Although the individual biomarkers HOXA1, CLEC11A, and AK055957 poorly discriminated between cirrhotic HCC and cirrhosis with 47–60% sensitivity (AUCs 0.52–0.72) (Figure 1B, Table 1), the combination of DMMs demonstrated higher AUCs compared to single biomarkers (AUCs 0.84–0.86).