TSPYL5 and hepatocellular carcinoma: To evaluate the findings from a previously published set of 4 DMMs that were all hypermethylated in cirrhotic HCC compared to cirrhosis [13] in our cohort, we first assessed, by means of qMSP, the methylation changes of HOXA1, CLEC11A, AK055957, and TSPYL5 in the liver tissue of 15 cirrhotic HCC and 30 cirrhosis patients with mixed etiologies (for patient details see Table S1).