NFKB1 and glioblastoma: Thus, Friedmann-Mezvinsky et al., using an RNA-Seq and bioinformatics analysis, identified genes enriched in GBM and designed a peptide denoted as NEMO-binding domain (NBD), which blocks the interaction of NEMO with the IKK (IkB)-kinase complex, thus inhibiting NF-kβ activity.