With our study, we aim to (1) review the relationship between the extent of resection (EOR) and OS with lung cancer BM after undergoing surgical resection; (2) evaluate the relationship among ALK and EGFR mutations with the rate of gross total resection (GTR), local control, and OS; and (3) discuss the targeted therapies administered for mutational lung cancer management and their potential role in local control and OS. The gene discussed is EGFR; the disease is lung cancer.