These observations imply that a tumor environment enriched in type 1 cytokines would result in an increased antigen presentation, proliferation, and cytolytic function of cytotoxic T-cells (CTLs) on one hand, and PD-L1 expression, growth arrest in G1/G0, HER2 oncogene inactivation, on the other hand, and consequently the apoptosis and senescence of the breast tumor [19,35,36,37,38]. This evidence concerns the gene ERBB2 and neoplasm.