Similarly, in a transgenic mouse model of spontaneous BC, it was shown that IL-25 promoted the recruitment of type 2 immune cells and facilitated lung metastasis, whereas blocking IL-25 remarkably decreased the type 2 response (Th2, M2-macrophages, and IL-10) in the tumor microenvironment but significantly increased the expression of IL-12 and the activity of CTLs to kill tumor cells [83]. This evidence concerns the gene IL25 and breast cancer.