Interestingly, the anticarcinogenic activity of metformin has been attributed to several mechanisms, including activation of liver kinase B1 (LKB1)/AMPK pathway, induction of cell cycle arrest and/or apoptosis, inhibition of protein synthesis, inhibition of unfolded protein response, activation of the immune system, and possible eradication of cancer stem cells [11]. The gene discussed is STK11; the disease is cancer.