In multivariate analysis, the independent prognostic factors associated with decreased OS in our MCL cohort were CNS involvement [HR: 3.12, 95% CI: 1.45–6.73, p = 0.004], TLS [HR: 2.79, 95% CI: 1.13–6.86, p = 0.026], albumin < 3.5 g/dL [HR: 2.69, 95% CI: 1.61–4.50, p < 0.001], failure to achieve remission after induction therapy [HR: 3.71, 95% CI: 2.07–6.67, p < 0.001], and omission of up-front ASCT [HR: 4.59, 95% CI: 2.23–9.42, p < 0.001]. Here, ALB is linked to mantle cell lymphoma.