Mantle cell lymphoma (MCL) is a malignancy characterized by clonal proliferation of small to medium-sized atypical B-lymphocytes with heterogeneous biological behavior and recurrently associated with the genetic rearrangement t(11;14) (q13;q32) and cyclin-D1 (CCND1) expression [1,2]. The gene discussed is CCND1; the disease is mantle cell lymphoma.