Similarly, we found that enhanced mesenchymal properties tend to occur in CDDP-resistant GC cells (high DKK1 expression) when compared to CDDP-sensitive GC cells (low DKK1 expression), as evidenced by the downregulation of E-cadherin, and the upregulation of N-cadherin and vimentin. This evidence concerns the gene CDH2 and gastric cancer.