The expression of Tspan8 in tumor tissues has been shown to be regulated by multiple transcription factors or mediators such as LMCR1 and p53 in melanoma [35,36], SOX9 in pancreatic cancer [37], by long non coding RNA SOX2-AS1 in lung adnocarcinoma [38], and by Lysine Specific Demethylase 1 (LDS1) in CRC [39]. This evidence concerns the gene SOX2 and melanoma.