OS would not be the first tumor in which IL-10 has a pathogenetic and metastatic role; in fact, its expression and its ability to shut down the inflammatory response, allowing tumor cells to grow, have been found in a variety of oncological contests, including breast tumors, renal cell carcinomas, non-small cell lung cancers, and melanoma [27,28,29,30,31,32]. This evidence concerns the gene IL10 and melanoma.