There was no significant difference between the IGHV mutated and unmutated groups for the p65 subunit (p = 0.4); however, RelB levels were higher in samples with unmutated IGHV genes (p = 0.001, despite the presence of one sample (CLL 104) that was an outlier with a very high RelB level in the ‘mutated IGHV’ group). The gene discussed is RELA; the disease is B-cell chronic lymphocytic leukemia.