These samples represented a range of B-ALL subtype defining alterations, including ETV6::RUNX1, BCR::ABL1, PAX5::JAK2, KMT2A::AFF1 and EP300::ZNF384 gene fusions, as well as PAX5.P80R and IKZF1.N159Y (Supplementary Table S9). Here, JAK2 is linked to acute lymphoblastic leukemia.