An HR+/HER2− patient who did not receive any ET had left cerebellum and lung metastases at the initial recurrence of breast cancer, underwent surgical tumor removal followed by stereotactic radiosurgery (SRS) for the brain metastasis, and then received sequential lines of chemotherapy with docetaxel (for 3 months) and capecitabine (for 44 months). This evidence concerns the gene HR and breast carcinoma.