Unlike the normal myeloblasts, however, CD34+ myeloblasts from AML M4/M5 expressed higher levels of SOX2 than those in NBM (MMI SOX2: 38.5 ± 6.4 vs. 11.3 ± 0.6, p = 0.0257). The gene discussed is SOX2; the disease is acute myeloid leukemia.