Reduced expression of OCT3/4, Nanog, and SOX-2 was observed in AML M4/M5 cells compared to normal HSCs (OCT3/4 MMI: 12.1 ± 1.4 vs. 41.5 ± 25.2, p = 0.0025; Nanog MMI: 12.6 ± 1.6 vs. 49.9 ± 30.2, p = 0.0025; SOX2 MMI: 12 ± 1.4 vs. 43.8 ± 17.8, p = 0.0158). This evidence concerns the gene SOX2 and acute myeloid leukemia.