Additionally, Picot et al. observed that OCT4 expression was higher in less differentiated leukemias, stage-specific embryonic antigen-1 (SSEA-1) levels were increased in more differentiated AML subtypes, and EA expression was variable between different leukemic cell subsets (CD34+CD38− versus CD34+CD38+) [7]. Here, POU5F1 is linked to acute myeloid leukemia.