While it is well known that YAP and TAZ can regulate cancer cell growth, survival, migration, and/or invasion depending on the cellular context and tumor type, recent reports have implicated YAP/TAZ signaling in the regulation of tumor cell plasticity mediated by hybrid and/or reversible EMT states and the promotion of cancer stem cell/progenitor phenotypes (Figure 3). The gene discussed is WWTR1; the disease is neoplasm.