WWTR1 and lung cancer: The inducible expression of constitutively active ABL2 in lung cancer cells resulted in increased TAZ phosphorylation on tyrosine Y321, which is a predicted ABL SH2 binding site found within the TAZ transactivation domain, and is adjacent to an phosphodegron sequence that mediates recognition by the β-TrCP ubiquitin E3 ligase (Figure 1).