FAT1 and squamous cell carcinoma: Recently, it was shown that loss-of-function of FAT1, a gene that encodes a proto-cadherin cell surface receptor, activates a CAMK2-CD44-SRC signaling pathway that induces YAP nuclear translocation and activation, leading to ZEB1 expression (Figure 2), which, in turn, promotes a hybrid EMT state, and increases metastasis in squamous cell carcinoma [53].