NSD2 and plasma cell myeloma: These arehyperdiploid myeloma (HDM) with gains of odd-numbered chromosomes [3] and non-hyperdiploid genomes with translocations of the IGH gene leading to overexpression of oncogenes through superenhancer hijacking—NSD2, previously known as MMSET (t(4;14)(p16;q32)), MAF (t(14;16)(q32;q23)), MAFB (t(14;20)(q32;q12)), CCND1 (t(11;14)(q13;q32)) and CCND3 (t(6;14)(p21;q32)) [4].