Since November 2020, the Food and Drug Administration (FDA) granted regular approval to pembrolizumab, an anti-programmed cell death protein 1 (PD-1) monoclonal antibody, in combination with chemotherapy for patients with locally recurrent unresectable or metastatic triple-negative breast cancer (TNBC) whose tumors express programmed-death ligand 1 (PD-L1) with a combined positive score (CPS) of more than 10 [1]. The gene discussed is CD274; the disease is triple-negative breast carcinoma.