CD274 and cancer: Considering that around 20% of TNBC tissues are PD-L1 positive and that overall response to PD-1/PD-L1 blockade therapies in that population ranges from 10 to 18.5% [49], while there are studies for several cancer types reporting efficacy of ICI in PD-L1 negative tumors [81,82], it is clear there is a gap in the recognition of best candidates to immunotherapy.