In general, the cancer-immunity cycle can be divided into seven steps, and lncRNAs are known to participate in all of them: (1) cancer cells release antigens; (2) antigens are captured by dendritic cells (DCs), (3) DCs with captured antigens migrate to lymph node and prime with T cells to activate tumor-specific cytotoxic CD8+ T cells, (4) the cytotoxic T cells migrate from lymph node into blood vessels, (5) immune cells infiltrate into tumor stroma, (6) the cytotoxic T cells recognize tumor cells and (7) T cells kill cancer cells [32]. This evidence concerns the gene CD8A and cancer.