The phosphorylation of Y1349 and Y1356 at the multifunctional docking site domain results in the recruitment of SH2 domain-containing proteins to the receptor complex and subsequent activation of downstream pathways such as PI3K/Akt/mTOR, MEK/ERK, and STAT3 signaling axes, which can promote tumorigenesis in diverse tumors, including HCC [10,14,17]. This evidence concerns the gene STAT3 and hepatocellular carcinoma.