Furthermore, the administration of 27 g/day of flavonoid-enriched chocolate (containing 850 mg flavan-3-ols (90 mg epicatechin) and 100 mg isoflavones) to patients with type 2 diabetes, for one year, reduced peripheral insulin resistance, improved insulin sensitivity, and led to a decrease in total cholesterol to HDL-c ratio and a decrease in LDL-c [57]. Here, INS is linked to Insulin resistance.