A one-year treatment with genistein at a daily dose of 54 mg of Caucasian postmenopausal women with metabolic syndrome resulted in a decrease in fasting glucose, fasting insulin, insulin resistance, total cholesterol, LDL-C, triglycerides, visfatin, and homocysteine and an increase in HDL-c and adiponectin [56]. The gene discussed is INS; the disease is Insulin resistance.