In an in vitro study, PC12 cells treated with H2O2 reduce pro-inflammatory markers associated with obesity, such as C-reactive protein (CRP), interleukin (IL)-6, and tumor necrosis factor (TNF)-α, leading to reduced oxidativestress-induced neurotoxicity in PC12 cells treated with H2O2 [202,207]. The gene discussed is TNF; the disease is obesity due to melanocortin 4 receptor deficiency.