It is worth adding that recent publications show a connection between inflammation and the regulation of intraneuronal signals (Semaphorins 3A class, Sema3A) which exist in activated microglia cells present in the hypoxic retina and which damage the endothelium of the retina blood vessels, contributing this way to the pathogenesis of ROP [1]. This evidence concerns the gene SEMA3A and retinopathy of prematurity.