SLC5A2 and cyst: It has also been reported that dual inhibition of SGLT1 and SGLT2 by phlorizin decreased cyst growth in Han:SPRD rats [23], whereas dapagliflozin was not associated with a decrease in cyst growth in those rats [24], suggesting that increased glucose reabsorption via SGLT1 by treatment with an SGLT2 inhibitor possibly increases cyst growth in late proximal tubules.