Different therapeutic approaches were tried in the past, including splenectomy, androgens, steroids and lithium, without any success [6], but the availability of granulocyte colony-stimulating factor (G-CSF) has revolutionized the management and natural history of cyclic neutropenia [8]; administration of myeloid growth factor or G-CSF is currently the most efficacious therapy for cyclic neutropenia, with a good clinical response [8]. The gene discussed is CSF3; the disease is cyclic hematopoiesis.