In addition, studies have established significant links between sclerostin levels and aortic, carotid and coronary artery calcification [148,154,155] in non-dialysis CKD, with one study suggesting that sclerostin measurement appears to be more important than serum phosphate levels for detecting VC-associated risk factors in patients with CKD who are not undergoing dialysis [148]. Here, SOST is linked to chronic kidney disease.