COMT and Anxiety: In the same study, the author compared the effectiveness of dexmedetomide on the three genotypes, and the results showed that there was no significant difference in the degree of anxiety and pain between the GG, GA, and AA polymorphisms, while the GA polymorphism of the COMT gene did not affect the analgesic effect of dexmedetomide in delivery, which is similar to the results we obtained in our study in which we applied nitrous oxide.