ADAMTS13 and Genetic thrombotic microangiopathy: Thrombotic thrombocytopenic purpura (TTP) is a rare disease with an incidence estimated at around four cases per million, caused by a severe deficiency of the enzyme ADAMTS13 (A Disintegrin And Metalloproteinase with ThromboSpondin type 1 repeats, member 13), and is recognized as thrombotic microangiopathy (TMA) that is characterized by severe thrombocytopenia, hemolytic anemia, and ischemic organ failure [1,2].