ICAM1 and intrahepatic cholestasis: The importance of s-ICAM-1 in patients with extrahepatic and intrahepatic cholestasis has been described in numerous studies, which confirmed statistically significant correlations between s-ICAM-1 levels and GTTP activity, alkaline phosfatase (ALP) activity, aspartate aminotransferase (AST) activity, or bilirubin level [5,23].