The aim of the study was to evaluate tumour necrosis factor-α (TNF-α), interleukin-6 (IL-6), soluble intracellular adhesion molecules 1 (s-ICAM-1) and Epstein–Barr virus (EBV) DNA load levels as predictors of hepatological complications of EBV infection in children. This evidence concerns the gene ICAM1 and Epstein-Barr virus infection.