Another cause of chronic gastritis is autoimmune gastritis (AIG), an immune-mediated disorder characterized with the destruction of gastric parietal cells secondary to the presence of anti-parietal-cell antibodies (APCA), leading to the loss of intrinsic factor (IF), which may result in development of pernicious anemia and reduced gastric acid production [10]. This evidence concerns the gene CACNA1A and autoimmune gastritis.