INS and polycystic ovary syndrome: Overweight/obese PCOS women, with greater preferential abdominal fat accumulation, hyperandrogenism and insulin resistance [2], are at particular risk of developing lipotoxicity due to excess FFA uptake into non-adipose cells, in part from increased highly lipolytic intra-abdominal fat with impaired insulin suppression of lipolysis [81,82,94,108,109,110].