These chromatin remodeling patterns of PCOS stem cells accompany enrichment of binding motifs for transcription factors (TFs) of the activator protein-1 (AP-1) subfamily during early cell differentiation, with altered gene expression of adipogenic/angiogenic functions involving androgen–insulin interactions through transforming growth factor (TGF)-ß1 signaling [77]. This evidence concerns the gene INS and polycystic ovary syndrome.