AKR1C3 and polycystic ovary syndrome: These differentiating PCOS stem cells can overexpress the genes, peroxisome proliferator-activated receptor γ (PPARγ) and CCAAT enhancer binding protein a (CEBPa), in combination with increased AKR1C3 gene expression during adipocyte maturation in vitro (Figure 2) [79,98,100].