CYP17A1 and polycystic ovary syndrome: In PCOS theca cells, moreover, decreased expression of miR-130b-3b (i.e., a noncoding microRNA transcriptional repressor) correlates with increased DENND1A.V2 and CYP17A1 expression as well as with androgen synthesis [49,57], while three PCOS-specific gene variants of AMHR2 occur in regions of higher methylation and acetylation activity [51].