A post-transcription form of DENND1A, namely DENND1A.v2, is over-expressed in some PCOS women [47,48], with DENND1A.v2 over-expression in human theca cells increasing androgen biosynthesis/release, potentially through PCOS-candidate gene ZNF217 diminishing the theca cell expression of microRNA mIR-130b-3p, a noncoding microRNA transcriptional repressor [49]. Here, DENND1A is linked to polycystic ovary syndrome.