In doing so, healthy normal-weight PCOS women as defined by the NIH criteria show low-normal insulin sensitivity (Si) in frequently sampled intravenous glucose tolerance testing (FSIVGTT) in combination with preferential abdominal fat accumulation (i.e., android fat) as determined by total body dual-energy x-ray absorptiometry (DXA) [59,75,76]. The gene discussed is INS; the disease is polycystic ovary syndrome.