In SC abdominal adipose, over-expression of the LHCG receptor and under-expression of the insulin receptor in non-obese and obese PCOS women, respectively, accompany reciprocal DNA methylation patterns [55], while reciprocal changes of gene expression and DNA methylation also coexist in adipogenic pathways of overweight PCOS women [56]. Here, INSR is linked to polycystic ovary syndrome.