Large genome-wide association studies (GWAS) in cohorts of PCOS women and controls have identified several PCOS-susceptible loci in candidate genes involving gonadotropin secretion/action, androgen biosynthesis/gonadal function, insulin action/metabolism and follicle development [1,30,31,32,33,34,35,36,37,38]. The gene discussed is INS; the disease is polycystic ovary syndrome.