Moreover, considering the reports that the risk of type II diabetes is positively correlated with the expressed serum levels of ICAM-1 and E-selectin and that a high-cholesterol diet could increase the serum concentrations of ICAM-1 and VCAM-1, CAMs should not be overlooked from the perspective of metabolic functions [3,4]. Here, ICAM1 is linked to type 2 diabetes mellitus.