In this study, it was, for the first time, concerned that ATA induced cell autophagy and ferroptosis, two emerging types of non-apoptotic cell death currently playing important roles in colorectal cancer suppression [17,18], which was further evidenced via the involvement of the typical autophagic mTOR pathway and the positive regulatory PI3K-AKT pathway at the transcriptome level [19]. This evidence concerns the gene AKT1 and colorectal cancer.