CD274 and melanoma: The use of chloroquine and 3-methyladenine as pharmacologic autophagy inhibitors confirmed that both steady-state autophagy and autophagic flux are promoted by bladder-cell-intrinsic PD-L1 [116], contrary to the results described in melanoma and ovarian cancer cells, where starvation-induced autophagy was inhibited by an increase in mTORC1 and mTORC2 signals [130].