In addition, the Janus kinase/signal transducer and activator of transcription (JAK/STAT1) pathways, as crucial players in promoting the cellular responses induced by IFN-γ, have been implicated in the increased expression of PD-L1 in colorectal carcinoma, gastric cancer, and pancreatic cancer [75,76,77]. This evidence concerns the gene CD274 and familial pancreatic carcinoma.