In normal CD90(+) myofibroblasts/fibroblasts (CMFs), an upregulation of PD-L1 was reported after TLR4 activation, with involvement from the MyD88/JAK2/NF-κB pathways [93]; this finding is consistent with the interplay between high PD-L1 expression and TLR4 expression levels that has been reported in colorectal cancer [94]. This evidence concerns the gene CD274 and colorectal cancer.