The antibody 15cl12 [31] cannot bind to soluble IgE, which is advantageous as its concentration in pre-malignant IgE-monoclonal gammopathy of undetermined significance (MGUS) conditions as well as in IgE-MM can rise several thousand times above normal values, up to several mg/mL [32,33]. The gene discussed is IGHE; the disease is monoclonal gammopathy.