Deposition of hyperphosphorylated tau in the brain is a telling pathological trait shared by neurodegenerative tauopathies, including primary tauopathies such as tau-positive frontotemporal lobar dementia and Pick’s disease and secondary tauopathies such as Alzheimer’s disease and chronic traumatic encephalopathy [7]. Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.