The spatiotemporal distribution of tau precipitates correlates with the clinical manifestation of cognitive and neurological deficits in AD [53] and other disorders [54], suggesting a causal role for abnormal tau, a notion that is supported by the identification of P301L and other mutations in the MAPT gene in frontotemporal dementia with Parkinsonism linked to chromosome 17 (FTDP-17) [55]. This evidence concerns the gene MAPT and Alzheimer disease.