The brains of patients with tauopathies, such as Alzheimer’s disease, frontotemporal lobar degeneration (FTLD), Pick’s disease, corticobasal degeneration, or progressive supranuclear palsy, show protein aggregates of the microtubule-associated protein tau (also known as MAPT) [1]. The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.