However, in breast cancer cells, GPER is related to the stabilization of the actin cytoskeleton and the up-regulation of Yes-associated protein 1 (YAP) and transcriptional coactivator with a PDZ-binding domain (TAZ) via the activation of Gαq-11, phospholipase C beta (PLCβ)/PKC and Rho/Rho-associated protein kinase (ROCK) signaling [56]. The gene discussed is YAP1; the disease is breast cancer.