With regards to GPER tissue-specific activity, it is interesting that cancer types with determinate GPER activity develop metastases to organs where the receptor has the same effect, suggesting that if a cancer type is GPER pro-tumorigenic, its dispersion will affect an organ where the new tumor possibly has the same GPER activity, and a focused therapy against this receptor would control primary and metastatic tumors. This evidence concerns the gene GPER1 and cancer.