Beneath the clinical presentation of cognitive impairment and behavioral disturbances, AD presents distinctive pathological features, such as amyloid plaques as aggregated β-amyloid (Aβ) in the brain, hyperphosphorylation of tau protein leading to tangles in neurons, and reactivation of glial cells such as astrocytes and microglia [5]. The gene discussed is MAPT; the disease is Alzheimer disease.