MDM2 and glioblastoma: In our study, HiChIP and RNA-seq results showed that the HDM2 promoter interacts with an enhancer by a new chromatin loop induced by glioblastoma ferroptosis (Figure 6A), and the expression of HDM2 is upregulated (Figure 5E), which suggests that change of chromatin loops induced change of HDM2 expression and then affected glioblastoma ferroptosis.