Importantly, p53 activation also leads to the DREAM-mediated repression of genes associated with syndromes of microcephaly (ASPM, BUB1, CASC5, CEP135, CEP152, CIT, LMNB1, NCAPD2, NCAPH, WDR62) or cerebellar hypoplasia (EXOSC3, MINPP1, NPHP1, TALPID3, TOE1, TSEN2), which might account for the brain-related phenotypes often observed in patients with DC [105], FA [100], and DBA [106] (Figure 1). The gene discussed is TP53; the disease is microcephaly.