An autopsy performed on a sporadic ALS patient with urinary and bowel dysfunction, which occurred in the early stage of the disease, revealed p-TDP-43-positive inclusions in the peripheral nerves within the thoracic sympathetic ganglia, as well as the IML of the thoracic spinal cord, but not in the Auerbach and Meissner plexuses of the esophagus and rectum, suggesting that the ENS was not very injured. This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.