Over time, the accumulated data led to a nuanced understanding of the pathogenesis of bone damage in conditions such as RA [6] and the demonstration of the effectiveness of denosumab, an anti-RANKL monoclonal antibody, in the prevention of bone erosions in RA, as shown in a recent phase III randomized clinical trial (RCT) [17]. Here, TNFSF11 is linked to rheumatoid arthritis.