Thus, the increase of circulating FGF21 was functionally contradictory to the observed increase in visceral adipose deposition in OVX mice, and vice versa in OVX+FGF21 LKO mice, implicating that the abrogative effects of FGF21 LKO on OVX-induced central obesity should be realized using mechanisms rather than lipolytic action of FGF21 directly in adipose tissues. Here, FGF21 is linked to Abdominal obesity.