SPHK2 and metabolic dysfunction-associated steatotic liver disease: Lacticaseibacillus rhamnosus GG increases the expression of hepatic FGF21 and adiponectin, resulting in the upregulation of SphK2 (Sphingosine kinase 2) and inactivation of PP2AC (protein phosphatase 2 catalytic subunit alpha), leading to reduced carbohydrate-responsive, element-binding protein (ChREBP) activity and fructose-induced reversal of NAFLD [36].