C4A and frontotemporal dementia: Further, the genes ADCYAP1R1 (−1.166) and GFAP (−3.088) were significantly down-regulated in FTD and were also down-regulated in breast invasive carcinoma (Figure 2B), whereas C4A (−2.71), which is significantly down-regulated in FTD, is significantly up-regulated (Figure 2B) and expressed in breast invasive carcinoma patients compared to the normal controls at a p-value < 0.05.