GRIA3 and frontotemporal dementia: In line with the reduced AMPA receptor-mediated releasing activity triggered by the FTD patient’s serum, the exposure of rat primary hippocampal neurons to the CSF of FTD patients with a high titer of circulating anti-GluA3 autoantibodies decreased the synaptic localization of the AMPA receptors and caused a concomitant loss of dendritic spines [58].