GRIN1 and psychotic disorder: To this aim, the CSF, sera, or specific human anti-NMDA autoantibodies isolated from patients suffering from encephalitis or psychosis [15,16,81,82], as well as human-derived anti-GluN1 monoclonal antibodies produced by human memory B-cells [19], were analyzed in in vitro models (brain slices, cultured hippocampal neurons, cultured HEK cells) to highlight neuronal changes that could determine the symptoms that typify autoimmune neuropathies in humans [5].