In both cases, the autoimmune encephalitis emerged as a polymorphic epilepsia partialis continua, status epilepticus and progressive aphasia, were typified by an MRI pattern compatible with encephalitis and, as a matter of fact, the analysis of the CSF and the serum unveiled a high titer of antibodies against the GluA3 subunit. Here, GRIA3 is linked to autoimmune encephalitis.