DIO3 and hypothyroidism: Local hypothyroidism is consistent with the differential expression of pancreatic deiodinases: low Dio1 (0.3 ± 0.07 vs. 1.4 ± 0.2) and high Dio3 (2.4 ± 0.7 vs. 0.8 ± 0.2) (Figure 2B).