Zebrafish have high conservatism with humans in terms of genes, sharing orthologs with more than 70% of all human genes [33], including genes implicated in the pathology of ALS (SOD1, TARDBP, C9orf72, and FUS) [268], with these genes having been utilized to generate zebrafish ALS models. The gene discussed is C9orf72; the disease is amyotrophic lateral sclerosis.