The cytokine storm profile in COVID-19 resembles sHLH and is characterized by increased levels of interleukins (IL-1β, IL-6, IL-8, IL-18), interferon-γ (IFNγ), granulocyte colony-stimulating factor (G-CSF), monocyte chemoattractant protein 1 (MCP-1/CCL2), macrophage inflammatory protein (MIP), and TNF-α. This evidence concerns the gene IL1B and COVID-19.